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What do these blood tests mean?

People diagnosed with a bleeding disorder may have extensive blood work drawn on a regular basis. While not everyone is a walking medical dictionary these tests are really not all that difficult to understand.

First your tests are simply a set of results that need to be compared with the norms. If you're looking at your blood test results, it should tell you the norm or give you a reference range as well as your result. Blood test results typically are assigned a positive/negative or numerical value. Positive and negative results are pretty self explanatory if you know what you were being tested for. For results with a numerical value, the test should also list a range that value is expected to be in. Once you've located this information, you're well on your way to having a basic understanding of that test's meaning.

Below is a list of common blood work and what it means. As always, the information provided here is only meant as a basic guide. You should consult your doctor for specific questions and explanations. If you would like more information on your blood work we also encourage you to check out Lab Tests Online, a website where you can find out the details about most blood tests.

Blood work for:

Bleeding Disorders
Hepatitis C
HIV

 

Common Blood Work for Bleeding Disorders
Order Test(s)

 Possible reasons to have ordered.

CBC (Complete Blood Count)

WBC (Number of White Blood Cells)

Routine
RBC (Number of Red Blood Cells)
Hgb (Amount of Hemoglobin)
Hct (Hematocrit)
MCV (Mean Corpuscular Volume)
MCH (Mean Corpuscular Hemoglobin)
MCHC (Mean Hemoglobin Concentration)
PLT (Platelet Count)
MPV (Platelet Volume)

Coagulation Factor Assay /
Coagulation Factor Activity

Factor I (Fibrinogen)

To diagnose and monitor a bleeding disorder as well as useed to establish a treatment regimen and determine the effectiveness of it.
Factor II (Prothrombin)
Factor III
Factor V
Factor VII
Factor VIII (Antihemophilic factor A)
Factor IX (Antihemophilic factor B)
Factor X
Factor XI
Factor XIII
Clotting Factor Inhibitor Clotting Factor Inhibitor Screening
If treatment is not working as well as expected or to monitor a known inhibitor.
Clotting Factor Antigen Factor Antigen
If clotting factor activity is found to be low.
Partial Thromboplastin Time PTT (Partial Thromboplastin Time)
This is often used to monitor the effectiveness of treatment for a person with a bleeding disorder.
Platelet Aggregation Studies

PFT or PFA (Platelet Function Tests or Assays)

Primarily used to identify a platelet dysfunction.
Prothrombin Time PT (Prothrombin Time)
This is typically used to indicate the risk of bleeding.
Ristocetin Cofactor VWF:RCo (von Willebrand Ristocetin Cofactor)
Used to look at quality and effectiveness of von Willebrand factor.
Thrombin Time TT (Thrombin Time)
Often is used to narrow down the problem if the PTT is longer than expected.
von Willebrand Factor Antigen VWF:Ag (von Willebrand Factor Antigen)
Determines the quantity of von Willebrand factor.

 

Common Blood Work for Hepatitis C
Order Test(s)  Possible reasons to have ordered.

Liver Panel

LDH (Lactic Acid Dehydrogenase)
Routine
Alb (Albumin)
ALT (Alanine Transaminase)
AST (Aspartate Transaminase)
ALP (Alkaline Phosphatase)
TBIL or BILI (Total Bilirubin)
TP or A/G (Total Protein)
GGT (Gamma Glutamyl Transpeptidase)
PT (Prothrombin Time)

Hepatitis C Antibody

Anti-HCV

The test used to diagnose a person with Hepatitis C
HCV RNA
Rarely used in medicine today but can determine if treatment was completely successful by distinguishing between viral and non-viral Hepatitis.
HCV Viral Load
Routine
HCV Genotype
Needs to be done only once and can indicate how difficult treatment will be and what that treatment should consist of.
BMP (Basic Metabolic Panel) Creatinine
Routine
BUN (Blood Urea Nitrogen)
GGT (Gamma Glutamyl Transpeptidase)
Calcium
Sodium
Potassium
CO2 (carbon dioxide, bicarbonate)
Chloride

 

Common Blood Work for HIV
Order Test(s)  Possible reasons to have ordered.
HIV Antibody Testing HIV serology Original Diagnosis
HIV Viral Load Testing HIV Viral Load Routine / Monitoring effectiveness of treatment.
CD4 T-cells CD4 (T-Helper cells, absolute CD4) Routine / Monitoring Immune Health
HIV Genotypic Resistance Testing ARV Resistance Testing Used to determine the most effective medicines to treat with.
HIV Phenotypic Resistance Testing ARV Resistance Testing Used to determine the most effective medicines to treat with.
White Blood Cell Count WBC (Number of White Blood Cells) Routine / Monitoring Immune Health
CD8 T-cells CD8 (T-Suppressor cells) Routine / Monitoring Immune Health
CD4 Percentage CD4% Routine / Monitoring Immune Health

As always, the information provided here is a basic guide. You should consult your doctor for specific questions and explanations.

 

Blood Test Explanations:

Albumin - a test often used in screening for liver disorders by testing the concentration of the albumin protein. As a liver gets damaged, the concentration of albumin in the blood typically drops. Back to Hep C Tests

Alanine Transaminase - is an enzyme predominantly found in liver and kidney cells and often used as an early indicator of liver damage. As a liver becomes damaged it releases more Alanine Transaminase into the blood stream. Back to Hep C Tests

Alkaline Phosphatase - is an enzyme predominantly found in liver and bone cells and often used as an indicator of liver disease or bone disorder. ALP usually increases due to issues with bile ducts, liver damage, or liver and bone cancers. Back to Hep C Tests

Aspartate Transaminase - is an enzyme where the highest concentrations are found in the heart and liver. AST is often used to indicate liver disorder. As liver cells become injured they release AST into the blood stream. Back to Hep C Tests

Bilirubin, Total - is a dark yellow pigment that results from the partial break down of red blood cells. Normally a person's liver filters out the bilirubin, makes it water-soluble then sends it out to be broken down. If bilirubin counts get too high, a person may become jaundice. While there are several reasons that this can happen it is frequently due to blockages in bile ducts or the inability of the liver to process the bilirubin fast enough. Back to Hep C Tests

BUN (Blood Urea Nitrogen) - measures the amount of Nitrogen in the blood. The liver produces blood urea nitrogen (ammonia) as it breaks down proteins. The ammonia is then released into the blood stream where it is filtered out by the kidneys for excretion. If the liver is incapable of processing the proteins due to damage the BUN may drop as a result. In cases where the BUN is elevated either the liver is producing abnormally high amounts of ammonia or the kidneys are not filtering the ammonia as efficiently as they should. Back to Hep C Tests

Calcium - measures the amount of calcium in the blood sample. This is important because calcium is essential to blood clotting. Without enough calcium present a bleeding disorder is much more difficult to manage. Back to Hep C Tests

Carbon Dioxide, Bicarbonate - measures the amount of CO2 in the blood. Bicarbinate is an electrolyte and one of the key players in maintaining a pH balance in the body. This test is normally ran along with other tests to identify electrolyte imbalances. Back to Hep C Tests

CD4 T-cells - are lymphocytes also known as Helper Cells. CD4s are a large part of a person's immune response as identify foreign bodies and infected cells, "flagging" them for removal by the CD8s. Back to HIV Tests

CD4 Percentage - is simply the ratio of CD4 cells to all lymphocytes in the blood sample. CD4% = CD4/ (CD4 + CD8) This percentage is frequently used as an indicator of overall imune health. The higher the percentage usually means a stronger immune system. Back to HIV Tests

CD8 T-cells - are lymphocytes also known as suppressor cells. CD8 cells destroy infected cells, and produce antiviral substances that help fight infection. Back to HIV Tests

Chloride - is an electrolyte and helps regulate the hydration and pH balance in the body. Back to Hep C Tests

Clotting Factor Antigen - quantifies the number of factor protein molecules in the blood sample for a specific clotting factor. Back to Bleeding Disorders Tests

Clotting Factor Inhibitor - measures the quantity of antibodies to a specific clotting factor in the blood sample. Back to Bleeding Disorders Tests

Coagulation Factor Assay - looks at the activity level of the individual clotting factor protein in order to determine how many functional copies of that protein are present in the blood sample. Result are typically expressed as a percentage with 100% being a normal activity level. Back to Bleeding Disorders Tests

Creatinine - is a waste product released from the consumption of creatine by a person's muscles. Creatinine is produced at a very consistent rate and removed from the blood stream by the kidneys. An increase of creatinine in the blood stream can indicate kidney dysfunction. Back to Hep C Tests

Gamma Glutamyl Transpeptidase - is an enzyme found in many organs but the main source of GGT in the blood is the liver. GGT is normally the first enzyme to rise or fall with the change in liver function. While it is very sensitive this way it cannot indicate the cause of the change and is therefore not, by itself, considered to be a dependable indicator. Back to Hep C Tests

Hematocrit - is the percentage of the blood sample that is made up of red blood cells. This test can help determine the severity of ongoing bleeding as well as anemia and many other conditions. Back to Bleeding Disorders Tests

Hemoglobin - determines the amount of a protein called hemoglobin in the blood sample. This protein caries the oxygen and CO2 in the red blood cells and can indicate anemia if hemoglobin is too low. Back to Bleeding Disorders Tests

Hepatitis C Antibody - tests for antibodies to the Hepatitis C virus in the blood sample. This test can determine if somebody has been exposed to the HCV virus. Back to Hep C Tests

Hepatitis C Genotype - Tests for the type of HCV a person has. There are currently 6 types of HCV known and treatments may differ slightly depending on which type or variation of the virus a person has.Back to Hep C Tests

Hepatitis C Viral Load - Used to see the number of copies of the Hep C virus are in the person's blood and monitor it for treatment decisions. Back to Hep C Tests

Hepatitis C Virus RNA - actually looks at the genetic material contained within the HCV to determine if is actually viral or. This test distinguishes between current viral infection and past viral infection. (A person with a current viral infection may still see the HCV replicating and infection growing whereas a person with no remaining viral infection has no detectable copies of the virus that are still capable of replication.)Back to Hep C Tests

HIV Antibody Testing - looks for antibodies to HIV in the person's blood. Presence of antibodies means that the person has been exposed to HIV at some point in the past. Back to HIV Tests

HIV Genotypic Resistance Testing - Uses the genetics of the HIV strain somebody is infected with to determine what medications the strain is resistant to. These tests are expensive and only need to be repeated if mutation of the virus is suspected. Back to HIV Tests

HIV Phenotypic Resistance Testing - rather than looking at the genetics of the viral strain to determine what medications the virus is resistant to, this test actually looks at what resistances are being expressed by the virus. These tests are expensive and only need to be repeated if mutation of the virus is suspected. Back to HIV Tests

HIV Viral Load Testing - looks at the actual number of copies of the HIV virus found in the blood sample. This test is routinely used to monitor the effectiveness of treatment and suppression of the HIV virus. Back to HIV Tests

Lactic Acid Dehydrogenase - is an enzyme found in most of the cells of the body. This enzyme is released into the bloodstream whenever tissue cells get damaged. Since LDH is normally only present in small amounts the amount of LDH found can indicate the amount of damage being done. When isoenzymes are examined the location of the damage can also be narrowed down to indicate the cell types getting damaged. Back to Hep C Tests

Mean Corpuscular Hemoglobin - is mathmatically determined by dividing the result from the hemoglobin test by the red blood count. Back to Bleeding Disorders Tests

Mean Corpuscular Hemoglobin Concentration - is calculated by dividing the hemoglobin by the hematocrit. The MCHC level can be low due to blood loss over time, too little iron in the body, or any one of several other issues. Back to Bleeding Disorders Tests

Mean Corpuscular Volume - is generated by dividing the hematocrit by the red blood count. Doing so provides an average size of the red blood cells in the sample. A high MCV can be caused by liver disease and many other problems where as having a low MVC can be due to kidney disease, anemia, and others. Back to Bleeding Disorders Tests

Mean Platelet Volume - is the average size of the platelets found in a blood sample. Since over time platelets tend to decrease in size, elevation of the MPV may indicate that the body is producing platelets at a faster rate than normal (for any of various reasons) where a low MPV might be caused by the drop in production of platelets and indicate some serious autoimmune or bone marrow disease. Back to Bleeding Disorders Tests

Partial Thromboplastin Time - measures how long it takes for a clot to form in a blood sample. This is often used as a way to look at the effectiveness of a treatment regimen. Back to Bleeding Disorders Tests

Platelet Aggregation Studies - consists of a series of tests designed to look at how well the platelets are binding together. Back to Bleeding Disorders Tests

Platelet Count - (also known as thrombocyte count) is the number of platelets in a sample of blood. If platelet levels fall below 20,000 platelets/micro-liter spontaneous bleeding becomes a large concern. People with too many platelets run the risk of having embolisms cause by the platelets clumping together and blocking an artery. Back to Bleeding Disorders Tests

Potassium - is an electrolyte and helps regulate the hydration and pH balance in the body while also playing a large roll in muscle function. Back to Hep C Tests

Prothrombin Time - measures the time it takes for blood to form a clot. Back to Bleeding Disorders Tests; Back to Hep C Tests

Red Blood Count - determines the number of red blood cells present in the sample of blood. This test is normally looked at in conjunction with hemoglobin test results. For people with bleeding disorders abnormal drops in their RBC may indicate blood loss and possible bleeding the person may be unaware of. Back to Bleeding Disorders Tests

Ristocetin Cofactor - determines the effectiveness of the von Willebrand factor proteins in the blood sample. Back to Bleeding Disorders Tests

Sodium - is an electrolyte and helps regulate the hydration of the body while also playing a large roll in muscle and nerve function. Back to Hep C Tests

Thrombin Time - measures the time it takes for fibrinogen to turn into the fibrin needed in clot formation. Back to Bleeding Disorders Tests

Total Protein - looks at the amount of total protein (both albumin and globulin) found in the blood sample. This can be used as a good indicator of liver and kidney health. A/G siply means they are looing at the ratio of albumin to globulin. Back to Hep C Tests

von Willebrand Factor Antigen - looks at the quantity of the von Willebrand factor proteins in the blood sample. Back to Bleeding Disorders Tests

White Blood Count - determines the number of white blood cells present in the sample of blood. Abnormally high or low results may indicate infection or illness. Back to Bleeding Disorders Tests; Back to HIV Tests

 

**Information here was gathered from Lab Tests Online as well as the CDC and various other branches of the the United States Department of Health and Human Services


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